Dementia prevention trials

preDIVA (Prevention of Dementia by Intensive Vascular Care)
Published: Moll van Charante EP, Richard E, Eurelings LS, van Dalen JW, Ligthart SA, van Bussel EF, et al. Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial. Lancet. 2016.

FINGER (Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability)
Published: Ngandu T, Lehtisalo J, Solomon A, Levalahti E, Ahtiluoto S, Antikainen R, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015;385(9984):2255-63.

MAPT (Multidomain Alzheimer Preventive Trial)
Published: Andrieu S, Guyonnet S, Coley N, Cantet C, Bonnefoy M, Bordes S, et al. Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial. Lancet Neurol. 2017.

HATICE (Healthy Ageing Through Internet Counselling in the Elderly)
The experience from the three above mentioned RCTs was used to design a new internet-based intervention strategy targeting vascular risk factors to prevent cardiovascular disease and dementia. In an ongoing RCT 2725 elderly in three countries were included in a randomised controlled trial to investigate the efficacy of this internet-based intervention strategy. The assessments will be finished in December 2017 and the results will be published in a peer reviewed international journal.

Click here for the HATICE website.

MIND-AD (Multimodal preventive trials for Alzheimer’s Disease: towards multinational strategies)
The aim of MIND-AD is to identify effective prevention strategies for dementia and Alzheimer’s disease. The project is based on the synergistic use of data from several prevention trials in Europe. In a proof-of-concept multinational pilot trial (MIND-ADMINI) a prevention strategy for prodromal AD will be investigated. Overall, generated data will allow formulation of recommendations and guidelines for dementia prevention.

Click here for the MIND-AD site.