• Andrieu S, Coley N, Lovestone S, Aisen PS, Vellas B. Prevention of sporadic Alzheimer’s disease: lessons learned from clinical trials and future directions Lancet Neurol. 2015 Sep;14(9):926-44. doi: 10.1016/S1474-4422(15)00153-2. Epub 2015 Jul 23. Review. PMID: 26213339
  • Solomon A, Mangialasche F, Richard E, Andrieu S, Bennett DA, Breteler M, Fratiglioni L, Hooshmand B, Khachaturian AS, Schneider LS, Skoog I, Kivipelto M. Advances in the prevention of Alzheimer’s disease and dementia.  J Intern Med. 2014 Mar;275(3):229-50. doi: 10.1111/joim.12178.
  • Imtiaz B, Tolppanen AM, Kivipelto M, Soininen H. Future directions in Alzheimer’s disease from risk factors to prevention. Biochem Pharmacol. 2014 Apr 15;88(4):661-70. doi: 10.1016/j.bcp.2014.01.003. Epub 2014 Jan 10. Review.
  • Richard E, Andrieu S, Solomon A, Mangialasche F, Ahtiluoto S, van Charante EP, Coley N, Fratiglioni L, Neely AS, Vellas B, van Gool WA, Kivipelto M. Methodological challenges in designing dementia prevention trials – The European Dementia Prevention Initiative (EDPI). J Neurol Sci 2012;322:64-70
  • Richard E, Khachaturiani ES. Multi-Domain Prevention for a Multi-Factorial Disease. J Prev Alz Dis 2014;1:4-5 
  • Solomon A, Mangialasche F, Richard E, Andrieu S, Bennett DA, Breteler M, Fratiglioni L, Hooshmand B, Khachaturian AS, Skoog I, Schneider L, Kivipelto M. Advances in the prevention ofAlzheimer’s disease. J Int Med 2014;275:229-50
  • Richard E, Brayne C. Dementia prevention strategies – beyond the randomised controlled trial. J Prev Alz Dis 2014;2:62-6
  • Kivipelto M, Mangialasche F. Alzheimer disease: To what extent can Alzheimer disease be prevented? Nat Rev Neurol. 2014 Oct;10(10):552-3. doi: 10.1038/nrneurol.2014.170
  • Andrieu S, Coley N, Aisen P, Carrillo MC, DeKosky S, Durga J, Fillit H, Frisoni GB, Froelich L, Gauthier S, Jones R, Jönsson L, Khachaturian Z, Morris JC, Orgogozo JM, Ousset PJ, Robert P, Salmon E, Sampaio C, Verhey F, Wilcock G, Vellas B. Methodological Issues in Primary Prevention Trials for Neurodegenerative Dementia. J Alzheimers Dis 2009;16:235-270
  • Coley N, Andrieu S, Gardette V, Gillette-Guyonnet S, Sanz C, Vellas B, Grand A. Dementia prevention: methodological explanations for inconsistent results. Epidemiol Rev 2008;30:35-66


  • Jongstra S, Beishuizen C, Andrieu S, Barbera M, van Dorp M, van de Groep B, Guillemont J, Mangialasche F, van Middelaar T, van Charante EM, Soininen H, Kivipelto M, Richard E. Development and Validation of an Interactive Internet Platform for Older People: The Healthy Ageing Through Internet Counselling in the Elderly Study. Telemed J E Health. 2017 Feb;23(2):96-104. doi: 10.1089/tmj.2016.0066. Epub 2016 Jul 27. PMID: 27463120
  • Richard E, Jongstra S, Soininen H, Brayne C, Moll van Charante EP, Meiller Y, van der Groep B, Beishuizen CR, Mangialasche F, Barbera M, Ngandu T, Coley N, Guillemont J, Savy S, Dijkgraaf MG, Peters RJ, van Gool WA, Kivipelto M, Andrieu S. Healthy Ageing Through Internet Counselling in the Elderly: the HATICE randomised controlled trial for the prevention of cardiovascular disease and cognitive impairment. BMJ Open. 2016 Jun 10;6(6):e010806. doi: 10.1136/bmjopen-2015-010806. PMID: 27288376


  • Beishuizen CR, Coley N, Moll van Charante EP, van Gool WA, Richard E, Andrieu S. Determinants of Dropout and Nonadherence in a Dementia Prevention Randomized Controlled Trial: The Prevention of Dementia by Intensive Vascular Care Trial. J Am Geriatr Soc. 2017 Mar 6. doi: 10.1111/jgs.14834. [Epub ahead of print]
  • Moll van Charante EP, Richard E, Eurelings LS, van Dalen JW, Ligthart SA, van Bussel EF, Hoevenaar-Blom MP, Vermeulen M, van Gool WA. Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial. Lancet. 2016 Aug 20;388(10046):797-805. doi: 10.1016/S0140-6736(16)30950-3. Epub 2016 Jul 26.
  • Ligthart SA, van den Eerenbeemt KD, Pols J, van Bussel EF, Richard E, Moll van Charante EP. Perspectives of older people engaging in nurse-led cardiovascular prevention programmes: a qualitative study in primary care in the Netherlands. Br J Gen Pract. 2015 Jan;65(630):e41-8.doi: 10.3399/bjgp15X683149.
  • Richard E, v.d. Heuvel E, Moll van Charante EP, Achthoven L, Vermeulen M, Bindels PJE, Van Gool WA. Prevention of dementia by intensive vascular care (preDIVA); a cluster  randomized trial in progress. Alz Dis Assoc Dis 2009;23:198-204
  • Richard E, Ligthart SA, Moll van Charante EP, Van Gool WA. Methodological issues in a cluster-randomized trial to prevent dementia by intensive vascular care. J Nutr Health Aging 2010;14:315-17
  • Ligthart SA, Richard E, Moll van Charante EP, Van Gool WA. Cardiovascular risk factors in community-dwelling elderly – opportunities for prevention. Eur J Prev Cardiol 2012;19:1365-1372


  • Pentikäinen H, Ngandu T, Liu Y, Savonen K, Komulainen P, Hallikainen M, Kivipelto M, Rauramaa R, Soininen H. Cardiorespiratory fitness and brain volumes in men and women in the FINGER study. Age Ageing. 2017 Jan 6. doi: 10.1093/ageing/afw191. [Epub ahead of print]
  • T.E. Strandberg, E. Levälahti, T. Ngandu, A. Solomon, M. Kivipelto, for the FINGER Study Group Health-related quality of life in a multidomain intervention trial to prevent cognitive decline (FINGER) European Geriatric Medicine Volume 8, Issue 2, April 2017, Pages 164–167
  • Kulmala J, Ngandu T, Pajala S, Lehtisalo J, Levälahti E, Antikainen R, Laatikainen T, Oksa H, Peltonen M, Rauramaa R, Soininen H, Strandberg T, Tuomilehto J, Kivipelto M. Leisure-Time and Occupational Physical Activity in Early and Late Adulthood in Relation to Later Life Physical Functioning. J Phys Act Health. 2016 Oct;13(10):1079-1087. Epub 2016 Aug 16.
  • Ngandu T, Lehtisalo J, Solomon A, Levälahti E, Ahtiluoto S, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015 Mar 11. pii: S0140-6736(15)60461-5. doi: 10.1016/S0140-6736(15)60461-
  • Ngandu T, Lehtisalo J, Levälahti E, Laatikainen T, Lindström J, Peltonen M, Solomon A, Ahtiluoto S, Antikainen R, Hänninen T, Jula A, Mangialasche F, Paajanen T, Pajala S, Rauramaa R, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. Recruitment and baseline characteristics of participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)-a randomized controlled lifestyle trial. Int J Environ Res Public Health 2014;11:9345-9360.
  • Kivipelto M, Solomon A, Ahtiluoto S, Ngandu T, Lehtisalo J, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Nissinen A, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study design and progress. Alzheimers Dement 2013 Nov;9:657-665


  • Andrieu S, Guyonnet S, Coley N, Cantet C, Bonnefoy M, Bordes S, Bories L, Cufi MN, Dantoine T, Dartigues JF, Desclaux F, Gabelle A, Gasnier Y, Pesce A, Sudres K, Touchon J, Robert P, Rouaud O, Legrand P, Payoux P, Caubere JP, Weiner M, Carrié I, Ousset PJ, Vellas B; MAPT Study Group.  Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial.Lancet Neurol. 2017 Mar 27. pii: S1474-4422(17)30040-6. doi: 10.1016/S1474-4422(17)30040-6. [Epub ahead of print]
  • Bennys K, Gabelle A, Berr C, De Verbizier D, Andrieu S, Vellas B, Touchon J; MAPT-DSA Study group. Cognitive Event-Related Potential, an Early Diagnosis Biomarker in Frail Elderly Subjects: The ERP-MAPT-PLUS Ancillary Study. J Alzheimers Dis. 2017 Mar 29. doi: 10.3233/JAD-161012. [Epub ahead of print] PMID:28372327
  • de Souto Barreto P, Cesari M, Rolland Y, Salabert AS, Payoux P, Andrieu S, Vellas B; MAPT Study Group. Cross-Sectional and Prospective Associations Between β-Amyloid in the Brain and Chair Rise Performance in Nondementia Older Adults With Spontaneous Memory Complaints. J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):278-283. doi: 10.1093/gerona/glw195. Epub 2016 Sep 30.
  • Delrieu J, Andrieu S, Pahor M, Cantet C, Cesari M, Ousset PJ, Voisin T, Fougère B, Gillette S, Carrie I, Vellas B. Neuropsychological Profile of “Cognitive Frailty” Subjects in MAPT Study.  J Prev Alzheimers Dis. 2016 Jun;3(3):151-159.
  • Del Campo N, Payoux P, Djilali A, Delrieu J, Hoogendijk EO, Rolland Y, Cesari M, Weiner MW, Andrieu S, Vellas B; MAPT/DSA Study Group. Relationship of regional brain β-amyloid to gait speed. Neurology. 2016 Jan 5;86(1):36-43. doi: 10.1212/WNL.0000000000002235. Epub 2015 Dec 7.
  • Lilamand M, Cesari M, del Campo N, Cantet C, Soto M, Ousset PJ, Payoux P, Andrieu S, Vellas B; MAPT Study Group. Brain Amyloid Deposition Is Associated With Lower Instrumental Activities of Daily Living Abilities in Older Adults. Results From the MAPT Study. J Gerontol A Biol Sci Med Sci. 2016 Mar;71(3):391-7. doi: 10.1093/gerona/glv155. Epub 2015 Sep 29.
  • de Souto Barreto P, Andrieu S, Payoux P, Demougeot L, Rolland Y, Vellas B; Multidomain Alzheimer Preventive Trial/Data Sharing Alzheimer Study Group. Physical Activity and Amyloid-β Brain Levels in Elderly Adults with Intact Cognition and Mild Cognitive Impairment. J Am Geriatr Soc. 2015 Aug;63(8):1634-9. doi: 10.1111/jgs.13530. Epub 2015 Jul 22. PMID:26200930
  • Vellas B, Carrie I, Gillette-Guyonnet S, Touchon J, Dantoine T, Dartigues JF, Cuffi MN, Bordes S, Gasnier Y, Robert P, Bories L, Rouaud O, Desclaux F, Sudres K, Bonnefoy M, Pesce A, Dufouil C, Lehericy S, Chupin M, Mangin JF, Payoux P, Adel D, Legrand P, Catheline D, Kanony C, Zaim M, Molinier L, Costa N, Delrieu J, Voisin T, Faisant C, Lala F, Nourhashémi F, Rolland Y, Van Kan GA, Dupuy C, Cantet C, Cestac P, Belleville S, Willis S, Cesari M, Weiner MW, Soto ME, Ousset PJ, Andrieu S. MAPT STUDY: A MULTIDOMAIN APPROACH FOR PREVENTING ALZHEIMER’S DISEASE: DESIGN AND BASELINE DATA. J Prev Alzheimers Dis. 2014 Jun;1(1):13-22.
  • Carrié I, Van Kan GA, Gillette-Guyonnet S, Andrieu S, Dartigues JF, Touchon J, Dantoine T, Rouaud O, Bonnefoy M, Robert P, Cuffi MN, Bories L, Bordes S, Gasnier Y, Desclaux F, Sudres K, Pesce A, Vellas B. Recruitment strategies for preventive trials: The MAPT study (Multidomain Alzheimer Preventive Trial). J Nutr Health Aging 2012;16:355-359
  • Gilette-Guyonet S, Andrieu S, Dantoine T, Dartigues JF, Touchon J, Vellas B, MAPT Study Group.Commentary on ‘a roadmap for the prevention of dementia part II Leon Thal Symposium 2008.’ The multidomain Alzheimer preventive trial (MAPT): A new approach to the prevention of Alzheimer’s disease. Alzheimers Dement 2009;5:114-121.
  • Gillette Guyonnet S, Abellan Van Kan G, Andrieu S, Aquino JP, Arbus C, Becq JP, Berr C, Bismuth S, Chamontin B, Dantoine T, Dartigues JF, Dubois B, Fraysse B, Hergueta T, Hanaire H, Jeandel C, Lagleyre S, Lala F, Nourhashemi F, Ousset PJ, Portet F, Ritz P, Robert P, Rolland Y, Sanz C, Soto M, Touchon J, Vellas B. Prevention of progression to dementia in the elderly: rationale and proposal for a health-promoting memory consultation (an IANA Task Force). J Nutr Health Aging. 2008 Oct;12(8):520-9. PMID:18810298