Dementia prevention trials

preDIVA (Prevention of Dementia by Intensive Vascular Care)
Published: Moll van Charante EP, Richard E, Eurelings LS, van Dalen JW, Ligthart SA, van Bussel EF, et al. Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial. Lancet. 2016388(10046):797-805.

FINGER (Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability)
Published: Ngandu T, Lehtisalo J, Solomon A, Levalahti E, Ahtiluoto S, Antikainen R, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015;385(9984):2255-63.

MAPT (Multidomain Alzheimer Preventive Trial)
Published: Andrieu S, Guyonnet S, Coley N, Cantet C, Bonnefoy M, Bordes S, et al. Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial. Lancet Neurol. 2017;16(5):377-389.

HATICE (Healthy Ageing Through Internet Counselling in the Elderly)
The experience from the three above mentioned RCTs was used to design a new internet-based intervention strategy with coach support targeting vascular risk factors to prevent cardiovascular disease and dementia. In this RCT 2724 elderly in three countries were included in a randomised controlled trial to investigate the efficacy of this  intervention strategy.

The trial has been completed, the data have been cleaned and analyzed and the resulting manuscript has been submitted to a high ranking peer reviewed journal.

Click here for the HATICE website.

MIND-AD (Multimodal preventive trials for Alzheimer’s Disease: towards multinational strategies)
The aim of MIND-AD is to identify effective prevention strategies for dementia and Alzheimer’s disease. The project is based on the synergistic use of data from several prevention trials in Europe. In a proof-of-concept multinational pilot trial (MIND-ADMINI) a prevention strategy for prodromal AD will be investigated. Overall, generated data will allow formulation of recommendations and guidelines for dementia prevention.

Click here for the MIND-AD website.

PRODEMOS (Prevention of Dementia using Mobile Phone Applications)
The EDPI consortium is currently working on the PRODEMOS trial. PRODEMOS builds on the HATICE eHealth intervention that will be adapted to an mHealth platform for dementia prevention, specifically tailored to vulnerable populations in HIC and LMIC, and will be implemented in multiple settings in the UK and China to pave the way towards a scalable, global strategy for dementia risk reduction. The trial is expected to commence by the end of 2019.

Click here for the PRODEMOS website.