Dementia prevention trials

HATICE (Healthy Ageing Through Internet Counselling in the Elderly)
The experience from three previous RCTs (preDIVA, FINGER and MAPT) was used to design a new internet-based intervention strategy with coach support targeting vascular risk factors to prevent cardiovascular disease and dementia. In this RCT 2724 elderly in three countries were included in a randomised controlled trial to investigate the efficacy of this intervention strategy.

The trial has been completed, and the results have shown that older people can improve their lifestyle and adopt healthier behaviours with the support of an online coach. This way they can reduce their risk of cardiovascular disease and dementia. These results were published in The Lancet Digital Health on 14 November 2019. https://www.thelancet.com/journals/landig/article/PIIS2589-7500(19)30194-3/fulltext.

Click here for the HATICE website.

MIND-AD (Multimodal preventive trials for Alzheimer’s Disease: towards multinational strategies)
The aim of MIND-AD is to identify effective prevention strategies for dementia and Alzheimer’s disease. The project is based on the synergistic use of data from several prevention trials in Europe. In a proof-of-concept multinational pilot trial (MIND-ADMINI) a prevention strategy for prodromal AD will be investigated. Overall, generated data will allow formulation of recommendations and guidelines for dementia prevention.

PRODEMOS (Prevention of Dementia using Mobile Phone Applications)
The EDPI consortium is currently working on the PRODEMOS trial. PRODEMOS builds on the HATICE eHealth intervention that will be adapted to an mHealth platform for dementia prevention, specifically tailored to vulnerable populations in HIC and LMIC, and will be implemented in multiple settings in the UK and China to pave the way towards a scalable, global strategy for dementia risk reduction. The trial is expected to commence by the beginning of 2021.

Click here for the PRODEMOS website.