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  • Hafdi M, Hoevenaar-Blom MP, Richard E. Multi-domain interventions for the prevention of dementia and cognitive decline. Cochrane Database Syst Rev. 2021 Nov 8;11(11):CD013572.
  • den Brok MGHE, Hoevenaar-Blom MP, Coley N, Andrieu S, van Dalen J, Meiller Y, Guillemont J, Brayne C, van Gool WA, Moll van Charante EP, Richard E. The Effect of Multidomain Interventions on Global Cognition, Symptoms of Depression and Apathy – A Pooled Analysis of Two Randomized Controlled Trials. J Prev Alzheimers Dis. 2022;9(1):96-103. doi: 10.14283/jpad.2021.53.PMID: 35098979
  • Eggink E, Hafdi M, Hoevenaar-Blom MP, et al. Attitudes and views on healthy lifestyle interventions for the prevention of dementia and cardiovascular disease among older people with low socioeconomic status: a qualitative study in the Netherlands. BMJ Open 2022;12:e055984
  • Hafdi M, Eggink E, Hoevenaar-Blom MP, Witvliet MP, Andrieu S, Barnes L, Brayne C, Brooks R, Coley N, Georges J, van der Groep A, van Marwijk H, van der Meijden M, Song L, Song M, Wang Y, Wang W, Wang W, Wimo A, Ye X, van Charante EPM, Richard E. Design and Development of a Mobile Health (mHealth) Platform for Dementia Prevention in the Prevention of Dementia by Mobile Phone Applications (PRODEMOS) Project. Front Neurol. 2021 Dec 16;12:733878. doi: 10.3389/fneur.2021.733878. eCollection 2021.
  • Andre L, Giulioli C, Piau A, Bongard V, Richard E, Moll Van Charante E, Coley N, Andrieu S, for the PRODEMOS consortium. Telephone and smartphone-based interventions for cognitive and cardio-metabolic health in middle-aged and older adults: a systematic review. Accepted for publication in Clinical Interventions in Aging.
  • Coley N, Andre L, Hoevenaar-Blom MP, Ngandu T, Beishuizen C, Barbera M, van Wanrooij L, Kivipelto M, Soininen H, van Gool W, Brayne C, Moll van Charante E, Richard E, Andrieu S; HATICE study group; PRODEMOS study group. Factors Predicting Engagement of Older Adults With a Coach-Supported eHealth Intervention Promoting Lifestyle Change and Associations Between Engagement and Changes in Cardiovascular and Dementia Risk: Secondary Analysis of an 18-Month Multinational Randomized Controlled Trial. J Med Internet Res. 2022 May 9;24(5):e32006.
  • Eggink E, Hafdi M, Hoevenaar-Blom MP, Song M, Andrieu S, Barnes LE, Birck C, Brooks RL, Coley N, Ford E, Georges J, van der Groep A, van Gool WA, Handels R, Hou H, Li D, Liu H, Lyu J, van Marwijk H, van der Meijden M, Niu Y, Sadhwani S, Wang W, Wang Y, Wimo A, Ye X, Yu Y, Zeng Q, Zhang W, Wang W, Brayne C, Moll van Charante EP, Richard E. Prevention of dementia using mobile phone applications (PRODEMOS): protocol for an international randomised controlled trial. BMJ Open. 2021 Jun 9;11(6):e049762. doi: 10.1136/bmjopen-2021-049762.
  • Nicola Coley, Marieke P. Hoevenaar‐Blom, Jan‐Willem van Dalen, Eric P. Moll van Charante, Miia Kivipelto, Hilkka Soininen, Sandrine Andrieu, Edo Richard, PRODEMOS consortium, the preDIVA study group, the MAPT/DSA group, and the HATICE consortium. Dementia risk scores as surrogate outcomes for lifestyle‐based multidomain prevention trials—rationale, preliminary evidence and challengesAlzheimer’s Dement2020161674– 1685


  • Andrieu S, Coley N, Lovestone S, Aisen PS, Vellas B. Prevention of sporadic Alzheimer’s disease: lessons learned from clinical trials and future directions Lancet Neurol. 2015 Sep;14(9):926-44. doi: 10.1016/S1474-4422(15)00153-2. Epub 2015 Jul 23. Review. PMID: 26213339
  • Solomon A, Mangialasche F, Richard E, Andrieu S, Bennett DA, Breteler M, Fratiglioni L, Hooshmand B, Khachaturian AS, Schneider LS, Skoog I, Kivipelto M. Advances in the prevention of Alzheimer’s disease and dementia.  J Intern Med. 2014 Mar;275(3):229-50. doi: 10.1111/joim.12178.
  • Imtiaz B, Tolppanen AM, Kivipelto M, Soininen H. Future directions in Alzheimer’s disease from risk factors to prevention. Biochem Pharmacol. 2014 Apr 15;88(4):661-70. doi: 10.1016/j.bcp.2014.01.003. Epub 2014 Jan 10. Review.
  • Richard E, Andrieu S, Solomon A, Mangialasche F, Ahtiluoto S, van Charante EP, Coley N, Fratiglioni L, Neely AS, Vellas B, van Gool WA, Kivipelto M. Methodological challenges in designing dementia prevention trials – The European Dementia Prevention Initiative (EDPI). J Neurol Sci 2012;322:64-70
  • Richard E, Khachaturiani ES. Multi-Domain Prevention for a Multi-Factorial Disease. J Prev Alz Dis 2014;1:4-5 
  • Solomon A, Mangialasche F, Richard E, Andrieu S, Bennett DA, Breteler M, Fratiglioni L, Hooshmand B, Khachaturian AS, Skoog I, Schneider L, Kivipelto M. Advances in the prevention ofAlzheimer’s disease. J Int Med 2014;275:229-50
  • Richard E, Brayne C. Dementia prevention strategies – beyond the randomised controlled trial. J Prev Alz Dis 2014;2:62-6
  • Kivipelto M, Mangialasche F. Alzheimer disease: To what extent can Alzheimer disease be prevented? Nat Rev Neurol. 2014 Oct;10(10):552-3. doi: 10.1038/nrneurol.2014.170
  • Andrieu S, Coley N, Aisen P, Carrillo MC, DeKosky S, Durga J, Fillit H, Frisoni GB, Froelich L, Gauthier S, Jones R, Jönsson L, Khachaturian Z, Morris JC, Orgogozo JM, Ousset PJ, Robert P, Salmon E, Sampaio C, Verhey F, Wilcock G, Vellas B. Methodological Issues in Primary Prevention Trials for Neurodegenerative Dementia. J Alzheimers Dis 2009;16:235-270
  • Coley N, Andrieu S, Gardette V, Gillette-Guyonnet S, Sanz C, Vellas B, Grand A. Dementia prevention: methodological explanations for inconsistent results. Epidemiol Rev 2008;30:35-66


  • Edo Richard, Eric P Moll van Charante, Marieke P Hoevenaar-Blom, Nicola Coley, Mariagnese Barbera, Abraham van der Groep, Yannick Meiller,Francesca Mangialasche, Cathrien B Beishuizen, Susan Jongstra, Tessa van Middelaar, Lennard L Van Wanrooij, Tiia Ngandu, Juliette Guillemont, Sandrine Andrieu, Carol Brayne, Miia Kivipelto, Hilkka Soininen, Willem A Van Gool. Healthy ageing through internet counselling in the elderly (HATICE). Lancet Digital Health 2019; published online Nov 14.
  • Barbera M, Mangialasche F, Jongstra S, Guillemont J, Ngandu T, Beishuizen C, Coley N, Brayne C, Andrieu S, Richard E, Soininen H, Kivipelto M; HATICE study group. Designing an Internet-Based Multidomain Intervention for the Prevention of Cardiovascular Disease and Cognitive Impairment in Older Adults: The HATICE Trial. J Alzheimers Dis. 2018;62(2):649-663. doi: 10.3233/JAD-170858.
  • Beishuizen CR. Cardiovascular risk self-management in older people: Development and evaluation of an eHealth platform. PhD Thesis, University of Amsterdam, April 2018,
  • Hoevenaar-Blom MP, Guillemont J, Ngandu T, Beishuizen CRL, Coley N, Moll van Charante EP, Andrieu S, Kivipelto M, Soininen H, Brayne C, Meiller Y, Richard E. Improving data sharing in research with context-free encoded missing data. PLoS One. 2017 Sep 12;12(9):e0182362. doi: 10.1371/journal.pone.0182362. eCollection 2017
  • van Middelaar T, Beishuizen CRL, Guillemont J, Barbera M, Richard E, Moll van Charante EP; HATICE consortium. Engaging older people in an internet platform for cardiovascular risk self-management: a qualitative study among Dutch HATICE participants. BMJ Open. 2018 Jan 21;8(1):e019683. doi: 10.1136/bmjopen-2017-019683
  • van Middelaar T, Ivens SD, van Peet PG, Poortvliet RKE, Richard E, Pols AJ, Moll van Charante EP. Prescribing and deprescribing antihypertensive medication in older people by Dutch general practitioners: a qualitative study. BMJ Open. 2018 Apr 20;8(4):e020871
  • Jongstra S, Beishuizen C, Andrieu S, Barbera M, van Dorp M, van de Groep B, Guillemont J, Mangialasche F, van Middelaar T, van Charante EM, Soininen H, Kivipelto M, Richard E. Development and Validation of an Interactive Internet Platform for Older People: The Healthy Ageing Through Internet Counselling in the Elderly Study. Telemed J E Health. 2017 Feb;23(2):96-104. doi: 10.1089/tmj.2016.0066. Epub 2016 Jul 27. PMID: 27463120
  • Richard E, Jongstra S, Soininen H, Brayne C, Moll van Charante EP, Meiller Y, van der Groep B, Beishuizen CR, Mangialasche F, Barbera M, Ngandu T, Coley N, Guillemont J, Savy S, Dijkgraaf MG, Peters RJ, van Gool WA, Kivipelto M, Andrieu S. Healthy Ageing Through Internet Counselling in the Elderly: the HATICE randomised controlled trial for the prevention of cardiovascular disease and cognitive impairment. BMJ Open. 2016 Jun 10;6(6):e010806. doi: 10.1136/bmjopen-2015-010806. PMID: 27288376


  • van Middelaar T, van Dalen JW, van Gool WA, van den Born BH, van Vught LA, Moll van Charante EP, Richard E. Visit-To-Visit Blood Pressure Variability and the Risk of Dementia in Older People. J Alzheimers Dis. 2018;62(2):727-735.
  • van Middelaar T, van Vught LA, van Charante EPM, Eurelings LSM, Ligthart SA, van Dalen JW, van den Born BJH, Richard E, van Gool WA. Lower dementia risk with different classes of antihypertensive medication in older patients. J Hypertens. 2017 Oct;35(10):2095-2101.
  • Beishuizen CR, Coley N, Moll van Charante EP, van Gool WA, Richard E, Andrieu S. Determinants of Dropout and Nonadherence in a Dementia Prevention Randomized Controlled Trial: The Prevention of Dementia by Intensive Vascular Care Trial. J Am Geriatr Soc. 2017 Mar 6. doi: 10.1111/jgs.14834. [Epub ahead of print]
  • Moll van Charante EP, Richard E, Eurelings LS, van Dalen JW, Ligthart SA, van Bussel EF, Hoevenaar-Blom MP, Vermeulen M, van Gool WA. Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial. Lancet. 2016 Aug 20;388(10046):797-805. doi: 10.1016/S0140-6736(16)30950-3. Epub 2016 Jul 26.
  • Ligthart SA, van den Eerenbeemt KD, Pols J, van Bussel EF, Richard E, Moll van Charante EP. Perspectives of older people engaging in nurse-led cardiovascular prevention programmes: a qualitative study in primary care in the Netherlands. Br J Gen Pract. 2015 Jan;65(630):e41-8.doi: 10.3399/bjgp15X683149.
  • Richard E, v.d. Heuvel E, Moll van Charante EP, Achthoven L, Vermeulen M, Bindels PJE, Van Gool WA. Prevention of dementia by intensive vascular care (preDIVA); a cluster  randomized trial in progress. Alz Dis Assoc Dis 2009;23:198-204
  • Richard E, Ligthart SA, Moll van Charante EP, Van Gool WA. Methodological issues in a cluster-randomized trial to prevent dementia by intensive vascular care. J Nutr Health Aging 2010;14:315-17
  • Ligthart SA, Richard E, Moll van Charante EP, Van Gool WA. Cardiovascular risk factors in community-dwelling elderly – opportunities for prevention. Eur J Prev Cardiol 2012;19:1365-1372


  • Kivipelto M, Mangialasche F, Ngandu T; World Wide Fingers Network. World Wide Fingers will advance dementia prevention. Lancet Neurol. 2018 Jan;17(1):27.
  • Lehtisalo J, Ngandu T, Valve P, Antikainen R, Laatikainen T, Strandberg T, Soininen H, Tuomilehto J, Kivipelto M, Lindström J. Nutrient intake and dietary changes during a 2-year multi-domain lifestyle intervention among older adults: secondary analysis of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) randomised controlled trial. Br J Nutr. 2017 Aug;118(4):291-302.
  • Marengoni A, Rizzuto D, Fratiglioni L, Antikainen R, Laatikainen T, Lehtisalo J, Peltonen M, Soininen H, Strandberg T, Tuomilehto J, Kivipelto M, Ngandu T. The Effect of a 2-Year Intervention Consisting of Diet, Physical Exercise, Cognitive Training, and Monitoring of Vascular Risk on Chronic Morbidity-the FINGER Randomized Controlled Trial. J Am Med Dir Assoc. 2018 Apr;19(4):355-360.e1.
  • Rosenberg A, Ngandu T, Rusanen M, Antikainen R, Bäckman L, Havulinna S, Hänninen T, Laatikainen T, Lehtisalo J, Levälahti E, Lindström J, Paajanen T, Peltonen M, Soininen H, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Solomon A, Kivipelto M. Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial. Alzheimers Dement. 2018 Mar;14(3):263-270.
  • Sindi S, Ngandu T, Hovatta I, Kåreholt I, Antikainen R, Hänninen T, Levälahti E, Laatikainen T, Lindström J, Paajanen T, Peltonen M, Khalsa DS, Wolozin B, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M, Solomon A; FINGER study group. Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial. J Alzheimers Dis. 2017;59(4):1459-1470.
  • Pentikäinen H, Ngandu T, Liu Y, Savonen K, Komulainen P, Hallikainen M, Kivipelto M, Rauramaa R, Soininen H. Cardiorespiratory fitness and brain volumes in men and women in the FINGER study. Age Ageing. 2017 Jan 6. doi: 10.1093/ageing/afw191. [Epub ahead of print]
  • T.E. Strandberg, E. Levälahti, T. Ngandu, A. Solomon, M. Kivipelto, for the FINGER Study Group Health-related quality of life in a multidomain intervention trial to prevent cognitive decline (FINGER) European Geriatric Medicine Volume 8, Issue 2, April 2017, Pages 164–167
  • Kulmala J, Ngandu T, Pajala S, Lehtisalo J, Levälahti E, Antikainen R, Laatikainen T, Oksa H, Peltonen M, Rauramaa R, Soininen H, Strandberg T, Tuomilehto J, Kivipelto M. Leisure-Time and Occupational Physical Activity in Early and Late Adulthood in Relation to Later Life Physical Functioning. J Phys Act Health. 2016 Oct;13(10):1079-1087. Epub 2016 Aug 16.
  • Ngandu T, Lehtisalo J, Solomon A, Levälahti E, Ahtiluoto S, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015 Mar 11. pii: S0140-6736(15)60461-5. doi: 10.1016/S0140-6736(15)60461-
  • Ngandu T, Lehtisalo J, Levälahti E, Laatikainen T, Lindström J, Peltonen M, Solomon A, Ahtiluoto S, Antikainen R, Hänninen T, Jula A, Mangialasche F, Paajanen T, Pajala S, Rauramaa R, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. Recruitment and baseline characteristics of participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)-a randomized controlled lifestyle trial. Int J Environ Res Public Health 2014;11:9345-9360.
  • Kivipelto M, Solomon A, Ahtiluoto S, Ngandu T, Lehtisalo J, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Nissinen A, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study design and progress. Alzheimers Dement 2013 Nov;9:657-665


  • Andrieu S, Guyonnet S, Coley N, Cantet C, Bonnefoy M, Bordes S, Bories L, Cufi MN, Dantoine T, Dartigues JF, Desclaux F, Gabelle A, Gasnier Y, Pesce A, Sudres K, Touchon J, Robert P, Rouaud O, Legrand P, Payoux P, Caubere JP, Weiner M, Carrié I, Ousset PJ, Vellas B; MAPT Study Group.  Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial.Lancet Neurol. 2017 Mar 27. pii: S1474-4422(17)30040-6. doi: 10.1016/S1474-4422(17)30040-6. [Epub ahead of print]
  • Bennys K, Gabelle A, Berr C, De Verbizier D, Andrieu S, Vellas B, Touchon J; MAPT-DSA Study group. Cognitive Event-Related Potential, an Early Diagnosis Biomarker in Frail Elderly Subjects: The ERP-MAPT-PLUS Ancillary Study. J Alzheimers Dis. 2017 Mar 29. doi: 10.3233/JAD-161012. [Epub ahead of print] PMID:28372327
  • de Souto Barreto P, Cesari M, Rolland Y, Salabert AS, Payoux P, Andrieu S, Vellas B; MAPT Study Group. Cross-Sectional and Prospective Associations Between β-Amyloid in the Brain and Chair Rise Performance in Nondementia Older Adults With Spontaneous Memory Complaints. J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):278-283. doi: 10.1093/gerona/glw195. Epub 2016 Sep 30.
  • Delrieu J, Andrieu S, Pahor M, Cantet C, Cesari M, Ousset PJ, Voisin T, Fougère B, Gillette S, Carrie I, Vellas B. Neuropsychological Profile of “Cognitive Frailty” Subjects in MAPT Study.  J Prev Alzheimers Dis. 2016 Jun;3(3):151-159.
  • Del Campo N, Payoux P, Djilali A, Delrieu J, Hoogendijk EO, Rolland Y, Cesari M, Weiner MW, Andrieu S, Vellas B; MAPT/DSA Study Group. Relationship of regional brain β-amyloid to gait speed. Neurology. 2016 Jan 5;86(1):36-43. doi: 10.1212/WNL.0000000000002235. Epub 2015 Dec 7.
  • Lilamand M, Cesari M, del Campo N, Cantet C, Soto M, Ousset PJ, Payoux P, Andrieu S, Vellas B; MAPT Study Group. Brain Amyloid Deposition Is Associated With Lower Instrumental Activities of Daily Living Abilities in Older Adults. Results From the MAPT Study. J Gerontol A Biol Sci Med Sci. 2016 Mar;71(3):391-7. doi: 10.1093/gerona/glv155. Epub 2015 Sep 29.
  • de Souto Barreto P, Andrieu S, Payoux P, Demougeot L, Rolland Y, Vellas B; Multidomain Alzheimer Preventive Trial/Data Sharing Alzheimer Study Group. Physical Activity and Amyloid-β Brain Levels in Elderly Adults with Intact Cognition and Mild Cognitive Impairment. J Am Geriatr Soc. 2015 Aug;63(8):1634-9. doi: 10.1111/jgs.13530. Epub 2015 Jul 22. PMID:26200930
  • Vellas B, Carrie I, Gillette-Guyonnet S, Touchon J, Dantoine T, Dartigues JF, Cuffi MN, Bordes S, Gasnier Y, Robert P, Bories L, Rouaud O, Desclaux F, Sudres K, Bonnefoy M, Pesce A, Dufouil C, Lehericy S, Chupin M, Mangin JF, Payoux P, Adel D, Legrand P, Catheline D, Kanony C, Zaim M, Molinier L, Costa N, Delrieu J, Voisin T, Faisant C, Lala F, Nourhashémi F, Rolland Y, Van Kan GA, Dupuy C, Cantet C, Cestac P, Belleville S, Willis S, Cesari M, Weiner MW, Soto ME, Ousset PJ, Andrieu S. MAPT STUDY: A MULTIDOMAIN APPROACH FOR PREVENTING ALZHEIMER’S DISEASE: DESIGN AND BASELINE DATA. J Prev Alzheimers Dis. 2014 Jun;1(1):13-22.
  • Carrié I, Van Kan GA, Gillette-Guyonnet S, Andrieu S, Dartigues JF, Touchon J, Dantoine T, Rouaud O, Bonnefoy M, Robert P, Cuffi MN, Bories L, Bordes S, Gasnier Y, Desclaux F, Sudres K, Pesce A, Vellas B. Recruitment strategies for preventive trials: The MAPT study (Multidomain Alzheimer Preventive Trial). J Nutr Health Aging 2012;16:355-359
  • Gilette-Guyonet S, Andrieu S, Dantoine T, Dartigues JF, Touchon J, Vellas B, MAPT Study Group.Commentary on ‘a roadmap for the prevention of dementia part II Leon Thal Symposium 2008.’ The multidomain Alzheimer preventive trial (MAPT): A new approach to the prevention of Alzheimer’s disease. Alzheimers Dement 2009;5:114-121.
  • Gillette Guyonnet S, Abellan Van Kan G, Andrieu S, Aquino JP, Arbus C, Becq JP, Berr C, Bismuth S, Chamontin B, Dantoine T, Dartigues JF, Dubois B, Fraysse B, Hergueta T, Hanaire H, Jeandel C, Lagleyre S, Lala F, Nourhashemi F, Ousset PJ, Portet F, Ritz P, Robert P, Rolland Y, Sanz C, Soto M, Touchon J, Vellas B. Prevention of progression to dementia in the elderly: rationale and proposal for a health-promoting memory consultation (an IANA Task Force). J Nutr Health Aging. 2008 Oct;12(8):520-9. PMID:18810298